| Tissue Specificity | Expression is restricted to epithelial cells. Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer.expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer.expression is increased relative to normal breast tissue. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis. |
| Protein Name | Ras-Related Protein Rab-25Catx-8 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic VesicleCell ProjectionPseudopodium MembraneColocalizes With Integrin Alpha-V/Beta-1 In Vesicles At The Pseudopodial TipsColocalizes With Rab11a In Subapical Vesicles |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-25 antibodyAnti-Catx-8 antibodyAnti-RAB25 antibodyAnti-CATX8 antibody |
Information sourced from Uniprot.org
