| Short Description : | Rabbit polyclonal RAB23 (1-237) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAB23 |
| Gene ID: | 51715 |
| Uniprot ID: | RAB23_HUMAN |
| Immunogen Region: | 1-237 |
| Immunogen Sequence: | MLEEDMEVAIKMVVVGNGAV GKSSMIQRYCKGIFTKDYKK TIGVDFLERQIQVNDEDVRL MLWDTAGQEEFDAITKAYYR GAQACVLVFSTTDRESFEAV SSWREKVVAEVGDIPTVLVQ NKIDLLDDSCIKNEEAEALA KRLKLRFYRTSVKEDLNVNE VFKYLAEKYLQKLKQQIAED PELTHSSSNKIGVFNTSGGS HSGQNSGTLNGGDVINLRPN KQRTKKNRNPFSSCSIP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human RAB23 (NP_057361.3). |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. |
| Protein Name | Ras-Related Protein Rab-23 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmCytoplasmic VesicleAutophagosomeEndosome MembranePhagosomePhagosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosis |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-23 antibodyAnti-RAB23 antibodyAnti-HSPC137 antibody |
Information sourced from Uniprot.org
