Anti-RAB20 antibody (130aa C-Term) (STJ140072)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
ImmunogenPurified recombinant peptide derived from within residues 130 aa to the C-terminus of Rab20 produced in E. coli.
General Information
| Short Description | Goat polyclonal RAB20, member RAS oncogene family (130aa C-Term) antibody for use in WB in human, mouse, rat, bovine, canine, chicken, avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep and simian samples. Datasheet inclu |
| Applications | WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Bovine/Canine/Chicken/Avian/Donkey/Feline/Goat/Guinea Pig/Hamster/Horse/Porcine/Rabbit/Sheep/Simian |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 2 mg/mL |
| Purification | This antibody is epitope-affinity purified from goat antiserum. |
| Dilution Range | WB 1:250-1:2000 |
| Formulation | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Storage Instruction | Store at-20 C for long-term storage. Store at 2-8 C for up to one month. |
Target Information
| Gene Symbol | RAB20 |
| Gene ID | 55647 |
| Uniprot ID | RAB20_HUMAN |
| Accession Number | ENSG00000139832 |
| Immunogen | Purified recombinant peptide derived from within residues 130 aa to the C-terminus of Rab20 produced in E. coli. |
| Immunogen Region | 130aa C-Term |
| Immunogen Sequence | MEGPASGKVGSCVSTKVPKQ EGPASGKVGSCVSTKVPKQV GPASGKVGSCVSTKVPKQVQ PASGKVGSCVSTKVPKQVQP ASGKVGSCVSTKVPKQVQPE SGKVGSCVSTKVPKQVQPED |
| Specificity | Detects Rab20 in transfected cells with GFP-Rab20 by Western blot. Detects levels of endogenous Rab20 (testis, liver and kidney) by Western blot. |
Additional Info
| Tissue Specificity | Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level). |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB20 plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. |
| Protein Name | Ras-Related Protein Rab-20 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Golgi ApparatusCytoplasmic VesiclePhagosomePhagosome MembraneLipid-AnchorCytoplasmic SideHighly Enriched On Apical Endocytic Structures In Polarized Epithelial Cells Of Kidney Proximal TubulesRecruited To Phagosomes Containing SAureus Or MTuberculosis |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-20 antibodyAnti-RAB20 antibody |
Information sourced from Uniprot.org