| Host: | Goat |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat/Bovine/Canine/Chicken/Avian/Donkey/Feline/Goat/Guinea Pig/Hamster/Horse/Porcine/Rabbit/Sheep/Simian |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal anti-RAB20, member RAS oncogene family (130aa C-Term) for use in WB in Human, Mouse, Rat, Bovine, Canine, Chicken, Avian, Donkey, Feline, Goat, Guinea Pig, Hamster, Horse, Porcine, Rabbit, Sheep and Simian samples. Datasheet included |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Purification: | This antibody is epitope-affinity purified from goat antiserum. |
| Concentration: | 2 mg/mL |
| Dilution Range: | WB 1:250-1:2000 |
| Storage Instruction: | Store at-20 C for long-term storage. Store at 2-8 C for up to one month. |
| Gene Symbol: | RAB20 |
| Gene ID: | 55647 |
| Uniprot ID: | RAB20_HUMAN |
| Immunogen Region: | 130aa C-Term |
| Accession Number: | ENSG00000139832 |
| Specificity: | Detects Rab20 in transfected cells with GFP-Rab20 by Western blot. Detects levels of endogenous Rab20 (testis, liver and kidney) by Western blot. |
| Immunogen: | Purified recombinant peptide derived from within residues 130 aa to the C-terminus of Rab20 produced in E. coli. |
| Immunogen Sequence: | MEGPASGKVGSCVSTKVPKQ EGPASGKVGSCVSTKVPKQV GPASGKVGSCVSTKVPKQVQ PASGKVGSCVSTKVPKQVQP ASGKVGSCVSTKVPKQVQPE SGKVGSCVSTKVPKQVQPED |
| Tissue Specificity | Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level). |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB20 plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. |
| Protein Name | Ras-Related Protein Rab-20 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Golgi ApparatusCytoplasmic VesiclePhagosomePhagosome MembraneLipid-AnchorCytoplasmic SideHighly Enriched On Apical Endocytic Structures In Polarized Epithelial Cells Of Kidney Proximal TubulesRecruited To Phagosomes Containing SAureus Or MTuberculosis |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-20 antibodyAnti-RAB20 antibody |
Information sourced from Uniprot.org
