| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pyrin and HIN domain-containing protein 1 (338-388 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PYHIN1 |
| Gene ID: |
149628 |
| Uniprot ID: |
IFIX_HUMAN |
| Immunogen Region: |
338-388 aa |
| Specificity: |
This antibody detects endogenous levels of IFIX at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human IFIX at the amino acid range 338-388 |
| Function | Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. |
| Protein Name | Pyrin And Hin Domain-Containing Protein 1Interferon-Inducible Protein X |
| Cellular Localisation | Isoform 1: NucleusNucleoplasmIsoform 3: NucleusIsoform 5: NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Pyrin And Hin Domain-Containing Protein 1 antibodyAnti-Interferon-Inducible Protein X antibodyAnti-PYHIN1 antibodyAnti-IFIX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
