Anti-PVRIG antibody (193-326) (STJ11104273)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Transmembrane Protein Pvrig (193-326) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PVRIG |
| Gene ID | 79037 |
| Uniprot ID | PVRIG_HUMAN |
| Immunogen Region | 193-326 |
| Immunogen Sequence | LRRHKHRPAPRLQPSRTSPQ APRARAWAPSQASQAALHVP YATINTSCRPATLDTAHPHG GPSWWASLPTHAAHRPQGPA AWASTPIPARGSFVSVENGL YAQAGERPPHTGPGLTLFPD PRGPRAMEGPLGVR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 193-326 of human PVRIG (NP_076975.2). |
Additional Info
| Tissue Specificity | Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells. |
| Function | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. |
| Protein Name | Transmembrane Protein PvrigCd112 ReceptorCd112rPoliovirus Receptor-Related Immunoglobulin Domain-Containing Protein |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Transmembrane Protein Pvrig antibodyAnti-Cd112 Receptor antibodyAnti-Cd112r antibodyAnti-Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein antibodyAnti-PVRIG antibodyAnti-C7orf15 antibody |
Information sourced from Uniprot.org