Anti-PUS7 antibody (352-661) (STJ11102927)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PUS7 (352-661) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PUS7 |
| Gene ID | 54517 |
| Uniprot ID | PUS7_HUMAN |
| Immunogen Region | 352-661 |
| Immunogen Sequence | ITGTDDQVQQAMNSLKEIGF INYYGMQRFGTTAVPTYQVG RAILQNSWTEVMDLILKPRS GAEKGYLVKCREEWAKTKDP TAALRKLPVKRCVEGQLLRG LSKYGMKNIVSAFGIIPRNN RLMYIHSYQSYVWNNMVSKR IEDYGLKPVPGDLVLKGATA TYIEEDDVNNYSIHDVVMPL PGFDVIYPKHKIQEAYREML TADNLDIDNMRHKIRDYSLS GAYRKIIIRPQNVSWEVVA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 352-661 of human PUS7 (NP_061915.2). |
Additional Info
| Function | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. |
| Protein Name | Pseudouridylate Synthase 7 Homolog |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase 7 Homolog antibodyAnti-PUS7 antibodyAnti-KIAA1897 antibody |
Information sourced from Uniprot.org