| Post Translational Modifications | Proteolytically cleaved during TRAIL-induced cell death. Cleaved, in vitro, either by caspase-3 (CASP3) or caspase-8 (CASP8). |
| Function | Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. |
| Protein Name | Trna Pseudouridine Synthase Pus10Hup10Coiled-Coil Domain-Containing Protein 139Trna Pseudouridine 55 SynthasePsi55 SynthaseTrna Pseudouridylate SynthaseTrna-Uridine Isomerase |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmMitochondrionLocalizes Mainly In The Nucleus (Probable)Trna Pseudouridylate Synthase Activity Is Restricted To The CytoplasmTranslocates From Nucleus To Mitochondria During Trail-Induced Apoptosis |
| Alternative Antibody Names | Anti-Trna Pseudouridine Synthase Pus10 antibodyAnti-Hup10 antibodyAnti-Coiled-Coil Domain-Containing Protein 139 antibodyAnti-Trna Pseudouridine 55 Synthase antibodyAnti-Psi55 Synthase antibodyAnti-Trna Pseudouridylate Synthase antibodyAnti-Trna-Uridine Isomerase antibodyAnti-PUS10 antibodyAnti-CCDC139 antibodyAnti-DOBI antibody |
Information sourced from Uniprot.org
