Anti-PTRH2 antibody (40-179) (STJ28549)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PTRH2 (40-179) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTRH2 |
| Gene ID | 51651 |
| Uniprot ID | PTH2_HUMAN |
| Immunogen Region | 40-179 |
| Immunogen Sequence | LPKSKTSKTHTDTESEASIL GDSGEYKMILVVRNDLKMGK GKVAAQCSHAAVSAYKQIQR RNPEMLKQWEYCGQPKVVVK APDEETLIALLAHAKMLGLT VSLIQDAGRTQIAPGSQTVL GIGPGPADLIDKVTGHLKLY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 40-179 of human PTRH2 (NP_057161.1). |
Additional Info
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. |
| Protein Name | Peptidyl-Trna Hydrolase 2 - MitochondrialPth 2Bcl-2 Inhibitor Of Transcription 1 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Peptidyl-Trna Hydrolase 2 - Mitochondrial antibodyAnti-Pth 2 antibodyAnti-Bcl-2 Inhibitor Of Transcription 1 antibodyAnti-PTRH2 antibodyAnti-BIT1 antibodyAnti-PTH2 antibodyAnti-CGI-147 antibody |
Information sourced from Uniprot.org