Anti-PTPRH antibody (1031-1081 aa) (STJ194247)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PTPRH at the amino acid range 1031-1081
General Information
| Short Description | Rabbit polyclonal anti-Receptor-type tyrosine-protein phosphatase H (1031-1081 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPRH |
| Gene ID | 5794 |
| Uniprot ID | PTPRH_HUMAN |
| Immunogen | Synthesized peptide derived from the human PTPRH at the amino acid range 1031-1081 |
| Immunogen Region | 1031-1081 aa |
| Specificity | This antibody detects endogenous levels of PTPRH at Human |
Additional Info
| Function | Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase HR-Ptp-HStomach Cancer-Associated Protein Tyrosine Phosphatase 1Sap-1Transmembrane-Type Protein-Tyrosine Phosphatase Type H |
| Database Links | |
| Cellular Localisation | Cell ProjectionMicrovillus MembraneSingle-Pass Type I Membrane ProteinApical Cell MembraneCytoplasmColocalizes With Ceacam20 At The Apical Brush Border Of Intestinal Cells |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase H antibodyAnti-R-Ptp-H antibodyAnti-Stomach Cancer-Associated Protein Tyrosine Phosphatase 1 antibodyAnti-Sap-1 antibodyAnti-Transmembrane-Type Protein-Tyrosine Phosphatase Type H antibodyAnti-PTPRH antibodyAnti-SAP1 antibody |
Information sourced from Uniprot.org