| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPRF |
| Gene ID: | 5792 |
| Uniprot ID: | PTPRF_HUMAN |
| Immunogen Region: | 1016-1250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1016-1250 of human PTPRF (NP_002831.2). |
| Immunogen Sequence: | KNFRVAAAMKTSVLLSWEVP DSYKSAVPFKILYNGQSVEV DGHSMRKLIADLQPNTEYSF VLMNRGSSAGGLQHLVSIRT APDLLPHKPLPASAYIEDGR FDLSMPHVQDPSLVRWFYIV VVPIDRVGGSMLTPRWSTPE ELELDELLEAIEQGGEEQRR RRRQAERLKPYVAAQLDVLP ETFTLGDKKNYRGFYNRPLS PDLSYQCFVLASLKEPMDQK RYASSPYSDEIVVQV |
| Function | Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase FLeukocyte Common Antigen RelatedLar |
| Database Links | Reactome: R-HSA-388844Reactome: R-HSA-77387Reactome: R-HSA-8849932 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase F antibodyAnti-Leukocyte Common Antigen Related antibodyAnti-Lar antibodyAnti-PTPRF antibodyAnti-LAR antibody |
Information sourced from Uniprot.org