| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-PTPN6/SHP1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | IHC-5µg/mlELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PTPN6 |
| Gene ID: | 5777 |
| Uniprot ID: | PTN6_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_536858.1; NP_002822.2 |
| Specificity: | This antibody is expected to recognise both reported isoforms (NP_536858.1and NP_002822.2). Please note this antibody was designed using the mouse sequence, which differs by 1 amino acid from the human sequence. |
| Immunogen Sequence: | KASRTSSKHKEE |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation. Phosphorylation at Tyr-564 enhances phosphatase activity. |
| Function | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 6Hematopoietic Cell Protein-Tyrosine PhosphataseProtein-Tyrosine Phosphatase 1cPtp-1cProtein-Tyrosine Phosphatase Shp-1Sh-Ptp1 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1433559Reactome: R-HSA-201556Reactome: R-HSA-210990Reactome: R-HSA-388841Reactome: R-HSA-389948Reactome: R-HSA-391160Reactome: R-HSA-432142Reactome: R-HSA-512988Reactome: R-HSA-5690714Reactome: R-HSA-6798695Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-9008059Reactome: R-HSA-909733Reactome: R-HSA-912526Reactome: R-HSA-912694Reactome: R-HSA-9705671Reactome: R-HSA-982772Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmNucleusIn NeuronsTranslocates Into The Nucleus After Treatment With Angiotensin IiShuttles Between The Cytoplasm And Nucleus Via Its Association With Pdpk1 |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 6 antibodyAnti-Hematopoietic Cell Protein-Tyrosine Phosphatase antibodyAnti-Protein-Tyrosine Phosphatase 1c antibodyAnti-Ptp-1c antibodyAnti-Protein-Tyrosine Phosphatase Shp-1 antibodyAnti-Sh-Ptp1 antibodyAnti-PTPN6 antibodyAnti-HCP antibodyAnti-PTP1C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
