| Host: | Rabbit |
| Applications: | WB/IF/IP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PTPN11 (1-460) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IF/ICC 1:50-1:200IP 1:1000-1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPN11 |
| Gene ID: | 5781 |
| Uniprot ID: | PTN11_HUMAN |
| Immunogen Region: | 1-460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-460 of human SHP2 (NP_002825.3). |
| Immunogen Sequence: | MTSRRWFHPNITGVEAENLL LTRGVDGSFLARPSKSNPGD FTLSVRRNGAVTHIKIQNTG DYYDLYGGEKFATLAELVQY YMEHHGQLKEKNGDVIELKY PLNCADPTSERWFHGHLSGK EAEKLLTEKGKHGSFLVRES QSHPGDFVLSVRTGDDKGES NDGKSKVTHVMIRCQELKYD VGGGERFDSLTDLVEHYKKN PMVETLGTVLQLKQPLNTTR INAAEIESRVRELSKLAET |
| Tissue Specificity | Widely expressed, with highest levels in heart, brain, and skeletal muscle. |
| Post Translational Modifications | Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation.which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA. Phosphorylated by activated PDGFRB. |
| Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 11Protein-Tyrosine Phosphatase 1dPtp-1dProtein-Tyrosine Phosphatase 2cPtp-2cSh-Ptp2Shp-2Shp2Sh-Ptp3 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-109704Reactome: R-HSA-110056Reactome: R-HSA-112411Reactome: R-HSA-114604Reactome: R-HSA-1170546Reactome: R-HSA-1257604Reactome: R-HSA-1295596Reactome: R-HSA-1433557Reactome: R-HSA-180292Reactome: R-HSA-186763Reactome: R-HSA-210990Reactome: R-HSA-210993Reactome: R-HSA-2219530Reactome: R-HSA-2586552Reactome: R-HSA-388841Reactome: R-HSA-389513Reactome: R-HSA-389948Reactome: R-HSA-391160Reactome: R-HSA-418886Reactome: R-HSA-432142Reactome: R-HSA-512988Reactome: R-HSA-5654689Reactome: R-HSA-5654693Reactome: R-HSA-5654695Reactome: R-HSA-5654700Reactome: R-HSA-5654706Reactome: R-HSA-5654710Reactome: R-HSA-5654712Reactome: R-HSA-5654720Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-6811558Reactome: R-HSA-877312Reactome: R-HSA-8853659Reactome: R-HSA-8854691Reactome: R-HSA-8865999Reactome: R-HSA-8934593Reactome: R-HSA-9008059Reactome: R-HSA-9028731Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-936964Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9674555Reactome: R-HSA-9680350Reactome: R-HSA-9702518Reactome: R-HSA-9703648Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 11 antibodyAnti-Protein-Tyrosine Phosphatase 1d antibodyAnti-Ptp-1d antibodyAnti-Protein-Tyrosine Phosphatase 2c antibodyAnti-Ptp-2c antibodyAnti-Sh-Ptp2 antibodyAnti-Shp-2 antibodyAnti-Shp2 antibodyAnti-Sh-Ptp3 antibodyAnti-PTPN11 antibodyAnti-PTP2C antibodyAnti-SHPTP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
