| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
HACD3 |
| Gene ID: |
51495 |
| Uniprot ID: |
HACD3_HUMAN |
| Immunogen Region: |
1-150 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PTPLAD1 (NP_057479.2). |
| Immunogen Sequence: |
MENQVLTPHVYWAQRHRELY LRVELSDVQNPAISITENVL HFKAQGHGAKGDNVYEFHLE FLDLVKPEPVYKLTQRQVNI TVQKKVSQWWERLTKQEKRP LFLAPDFDRWLDESDAEMEL RAKEEERLNKLRLESEGSPE TLTNLRKGYL |
| Tissue Specificity | Highly expressed in testis, kidney, brain, liver and weakly in skeletal muscle, spleen and heart. No expression detected in leukocytes. |
| Function | Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. |
| Protein Name | Very-Long-Chain3r-3-Hydroxyacyl-Coa Dehydratase 33-Hydroxyacyl-Coa Dehydratase 3Hacd3Butyrate-Induced Protein 1B-Ind1Hb-Ind1Protein-Tyrosine Phosphatase-Like A Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Very-Long-Chain antibodyAnti-3r-3-Hydroxyacyl-Coa Dehydratase 3 antibodyAnti-3-Hydroxyacyl-Coa Dehydratase 3 antibodyAnti-Hacd3 antibodyAnti-Butyrate-Induced Protein 1 antibodyAnti-B-Ind1 antibodyAnti-Hb-Ind1 antibodyAnti-Protein-Tyrosine Phosphatase-Like A Domain-Containing Protein 1 antibodyAnti-HACD3 antibodyAnti-BIND1 antibodyAnti-PTPLAD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
