| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-PTP4A1/PRL-1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 21kDa band observed in lysates of cell lines A549 and HeLa (calculated MW of 19.8kDa according to NP_003454.1). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PTP4A1 |
| Gene ID: | 7803 |
| Uniprot ID: | TP4A1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_003454.1 |
| Immunogen Sequence: | KDSNGHRNNCCIQ |
| Post Translational Modifications | Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus. |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. |
| Protein Name | Protein Tyrosine Phosphatase Type Iva 1Ptp(CaaxiProtein-Tyrosine Phosphatase 4a1Protein-Tyrosine Phosphatase Of Regenerating Liver 1Prl-1 |
| Cellular Localisation | Cell MembraneLipid-AnchorEarly EndosomeEndoplasmic ReticulumCytoplasmCytoskeletonSpindleNucleusAnd Mitotic Spindle |
| Alternative Antibody Names | Anti-Protein Tyrosine Phosphatase Type Iva 1 antibodyAnti-Ptp(Caaxi antibodyAnti-Protein-Tyrosine Phosphatase 4a1 antibodyAnti-Protein-Tyrosine Phosphatase Of Regenerating Liver 1 antibodyAnti-Prl-1 antibodyAnti-PTP4A1 antibodyAnti-PRL1 antibodyAnti-PTPCAAX1 antibody |
Information sourced from Uniprot.org
