Anti-PTGES antibody (1-100) (STJ11100566)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PTGES (1-100) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTGES |
| Gene ID | 9536 |
| Uniprot ID | PTGES_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MPAHSLVMSSPALPAFLLCS TLLVIKMYVVAIITGQVRLR KKAFANPEDALRHGGPQYCR SDPDVERCLRAHRNDMETIY PFLFLGFVYSFLGPNPFVAW |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTGES (NP_004869.1). |
Additional Info
| Function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively. |
| Protein Name | Prostaglandin E SynthaseGlutathione Peroxidase PtgesGlutathione Transferase PtgesMicrosomal Glutathione S-Transferase 1-Like 1Mgst1-L1Microsomal Prostaglandin E Synthase 1Mpges-1P53-Induced Gene 12 Protein |
| Database Links | Reactome: R-HSA-2162123 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear RegionColocalizes With Ptgs1/Cox-1 And Ptgs2/Cox-2 In The Perinuclear Compartment |
| Alternative Antibody Names | Anti-Prostaglandin E Synthase antibodyAnti-Glutathione Peroxidase Ptges antibodyAnti-Glutathione Transferase Ptges antibodyAnti-Microsomal Glutathione S-Transferase 1-Like 1 antibodyAnti-Mgst1-L1 antibodyAnti-Microsomal Prostaglandin E Synthase 1 antibodyAnti-Mpges-1 antibodyAnti-P53-Induced Gene 12 Protein antibodyAnti-PTGES antibodyAnti-MGST1L1 antibodyAnti-MPGES1 antibodyAnti-PGES antibodyAnti-PIG12 antibody |
Information sourced from Uniprot.org