| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTGER3 (1-53) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTGER3 |
| Gene ID: |
5733 |
| Uniprot ID: |
PE2R3_HUMAN |
| Immunogen Region: |
1-53 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-53 of human PGE receptor EP3 (PTGER3) (NP_942009.1). |
| Immunogen Sequence: |
MKETRGYGGDAPFCTRLNHS YTGMWAPERSAEARGNLTRP PGSGEDCGSVSVA |
| Tissue Specificity | Detected in kidney. Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. |
| Function | Receptor for prostaglandin E2 (PGE2). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium. Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality. |
| Protein Name | Prostaglandin E2 Receptor Ep3 SubtypePge Receptor Ep3 SubtypePge2 Receptor Ep3 SubtypePge2-RProstanoid Ep3 Receptor |
| Database Links | Reactome: R-HSA-391908Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostaglandin E2 Receptor Ep3 Subtype antibodyAnti-Pge Receptor Ep3 Subtype antibodyAnti-Pge2 Receptor Ep3 Subtype antibodyAnti-Pge2-R antibodyAnti-Prostanoid Ep3 Receptor antibodyAnti-PTGER3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
