Anti-PTCH1 nanobody [SAA1040] (STJN000268)

Anti-PTCH1 nanobody [SAA1040] (STJN000268)

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STJN000268
£195.50 - £1,319.50
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Protein Patched Homolog 1 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1040
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: PTCH1
Gene ID: 5727
Uniprot ID: PTC1_HUMAN
Post Translational Modifications Glycosylation is necessary for SHH binding. In the absence of Hh ligands, ubiquitination by ITCH at Lys-1426 promotes endocytosis and both proteasomal and lysosomal degradation.
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Protein Name Protein Patched Homolog 1
Ptc
Ptc1
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-5610787
Reactome: R-HSA-5632681
Reactome: R-HSA-5632684
Reactome: R-HSA-5635838
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Nanobody Names Anti-Protein Patched Homolog 1 nanobody
Anti-Ptc nanobody
Anti-Ptc1 nanobody
Anti-PTCH1 nanobody
Anti-PTCH nanobody

Information sourced from Uniprot.org

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