| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Paraspeckle component 1 (10-90 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PSPC1 |
| Gene ID: |
55269 |
| Uniprot ID: |
PSPC1_HUMAN |
| Immunogen Region: |
10-90 aa |
| Specificity: |
PSPC1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 10-90 |
| Function | Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Paraspeckle Component 1Paraspeckle Protein 1 |
| Cellular Localisation | NucleusNucleolusNucleus MatrixCytoplasmNucleus SpeckleIn Punctate Subnuclear Structures Often Located Adjacent To Splicing SpecklesCalled ParaspecklesColocalizes With Nono And Sfpq In Paraspeckles And Perinucleolar Caps In An Rna-Dependent MannerMay Cycle Between Paraspeckles And NucleolusIn TelophaseWhen Daughter Nuclei FormLocalizes To Perinucleolar Caps |
| Alternative Antibody Names | Anti-Paraspeckle Component 1 antibodyAnti-Paraspeckle Protein 1 antibodyAnti-PSPC1 antibodyAnti-PSP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
