| Tissue Specificity | Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue. |
| Post Translational Modifications | Degraded by the proteasome upon completion of 20S proteasome maturation. |
| Function | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. |
| Protein Name | Proteasome Assembly Chaperone 2Pac-2Hepatocellular Carcinoma-Susceptibility Protein 3Tumor Necrosis Factor Superfamily Member 5-Induced Protein 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Proteasome Assembly Chaperone 2 antibodyAnti-Pac-2 antibodyAnti-Hepatocellular Carcinoma-Susceptibility Protein 3 antibodyAnti-Tumor Necrosis Factor Superfamily Member 5-Induced Protein 1 antibodyAnti-PSMG2 antibodyAnti-HCCA3 antibodyAnti-PAC2 antibodyAnti-TNFSF5IP1 antibody |
Information sourced from Uniprot.org
