| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PSMD14 |
| Gene ID: | 10213 |
| Uniprot ID: | PSDE_HUMAN |
| Immunogen Region: | 160-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-300 of human PSMD14 (NP_005796.1). |
| Immunogen Sequence: | FRLINANMMVLGHEPRQTTS NLGHLNKPSIQALIHGLNRH YYSITINYRKNELEQKMLLN LHKKSWMEGLTLQDYSEHCK HNESVVKEMLELAKNYNKAV EEEDKMTPEQLAIKNVGKQD PKRHLEEHVDVLMTSNIVQC L |
| Tissue Specificity | Widely expressed. Highest levels in heart and skeletal muscle. |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. |
| Protein Name | 26s Proteasome Non-Atpase Regulatory Subunit 14 26s Proteasome Regulatory Subunit Rpn11 26s Proteasome-Associated Pad1 Homolog 1 |
| Database Links | Reactome: R-HSA-1169091 Reactome: R-HSA-1234176 Reactome: R-HSA-1236974 Reactome: R-HSA-1236978 Reactome: R-HSA-174084 Reactome: R-HSA-174113 Reactome: R-HSA-174154 Reactome: R-HSA-174178 Reactome: R-HSA-174184 Reactome: R-HSA-180534 Reactome: R-HSA-180585 Reactome: R-HSA-187577 Reactome: R-HSA-195253 Reactome: R-HSA-202424 Reactome: R-HSA-211733 Reactome: R-HSA-2467813 Reactome: R-HSA-2871837 Reactome: R-HSA-349425 Reactome: R-HSA-350562 Reactome: R-HSA-382556 Reactome: R-HSA-450408 Reactome: R-HSA-4608870 Reactome: R-HSA-4641257 Reactome: R-HSA-4641258 Reactome: R-HSA-5358346 Reactome: R-HSA-5362768 Reactome: R-HSA-5607761 Reactome: R-HSA-5607764 Reactome: R-HSA-5610780 Reactome: R-HSA-5610783 Reactome: R-HSA-5610785 Reactome: R-HSA-5632684 Reactome: R-HSA-5658442 Reactome: R-HSA-5668541 Reactome: R-HSA-5676590 Reactome: R-HSA-5678895 Reactome: R-HSA-5687128 Reactome: R-HSA-5689603 Reactome: R-HSA-5689880 Reactome: R-HSA-5689901 Reactome: R-HSA-6798695 Reactome: R-HSA-68867 Reactome: R-HSA-68949 Reactome: R-HSA-69017 Reactome: R-HSA-69481 Reactome: R-HSA-69601 Reactome: R-HSA-75815 Reactome: R-HSA-8852276 Reactome: R-HSA-8854050 Reactome: R-HSA-8939236 Reactome: R-HSA-8939902 Reactome: R-HSA-8941858 Reactome: R-HSA-8948751 Reactome: R-HSA-8951664 Reactome: R-HSA-9010553 Reactome: R-HSA-9020702 Reactome: R-HSA-9604323 Reactome: R-HSA-9755511 Reactome: R-HSA-9762114 Reactome: R-HSA-9824272 Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-26s Proteasome Non-Atpase Regulatory Subunit 14 antibody Anti-26s Proteasome Regulatory Subunit Rpn11 antibody Anti-26s Proteasome-Associated Pad1 Homolog 1 antibody Anti-PSMD14 antibody Anti-POH1 antibody |
Information sourced from Uniprot.org