| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Homologous-pairing protein 2 homolog is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PSMC3IP |
| Gene ID: |
29893 |
| Uniprot ID: |
HOP2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of HOP2 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human HOP2 |
| Post Translational Modifications | Phosphorylated by PKA, PKC and MAPK. |
| Function | Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. |
| Protein Name | Homologous-Pairing Protein 2 HomologNuclear Receptor Coactivator Gt198Psmc3-Interacting ProteinProteasome 26s Atpase Subunit 3-Interacting ProteinTat-Binding Protein 1-Interacting ProteinTbp-1-Interacting Protein |
| Database Links | Reactome: R-HSA-912446 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homologous-Pairing Protein 2 Homolog antibodyAnti-Nuclear Receptor Coactivator Gt198 antibodyAnti-Psmc3-Interacting Protein antibodyAnti-Proteasome 26s Atpase Subunit 3-Interacting Protein antibodyAnti-Tat-Binding Protein 1-Interacting Protein antibodyAnti-Tbp-1-Interacting Protein antibodyAnti-PSMC3IP antibodyAnti-HOP2 antibodyAnti-TBPIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
