| Post Translational Modifications | Phosphorylated by PKA, PKC and MAPK. |
| Function | Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. |
| Protein Name | Homologous-Pairing Protein 2 HomologNuclear Receptor Coactivator Gt198Psmc3-Interacting ProteinProteasome 26s Atpase Subunit 3-Interacting ProteinTat-Binding Protein 1-Interacting ProteinTbp-1-Interacting Protein |
| Database Links | Reactome: R-HSA-912446 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homologous-Pairing Protein 2 Homolog antibodyAnti-Nuclear Receptor Coactivator Gt198 antibodyAnti-Psmc3-Interacting Protein antibodyAnti-Proteasome 26s Atpase Subunit 3-Interacting Protein antibodyAnti-Tat-Binding Protein 1-Interacting Protein antibodyAnti-Tbp-1-Interacting Protein antibodyAnti-PSMC3IP antibodyAnti-HOP2 antibodyAnti-TBPIP antibody |
Information sourced from Uniprot.org
