| Short Description : | Rabbit monoclonal anti-PSMA4 for use in WB, IHC-F, IHC-P, ICC, IF and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-F/IHC-P/ICC/IF/IP |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | R08-8H3 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.3 mg/mL |
| Purification: | Affinity Purified |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:20 |
| Formulation: | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | PSMA4 |
| Gene ID: | 5685 |
| Uniprot ID: | PSA4_HUMAN |
| Immunogen: | A synthetic peptide of human PSMA4 |
| Function | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). |
| Protein Name | Proteasome Subunit Alpha Type-4Macropain Subunit C9Multicatalytic Endopeptidase Complex Subunit C9Proteasome Component C9Proteasome Subunit LProteasome Subunit Alpha-3Alpha-3 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1234176Reactome: R-HSA-1236974Reactome: R-HSA-1236978Reactome: R-HSA-174084Reactome: R-HSA-174113Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-180534Reactome: R-HSA-180585Reactome: R-HSA-187577Reactome: R-HSA-195253Reactome: R-HSA-202424Reactome: R-HSA-211733Reactome: R-HSA-2467813Reactome: R-HSA-2871837Reactome: R-HSA-349425Reactome: R-HSA-350562Reactome: R-HSA-382556Reactome: R-HSA-450408Reactome: R-HSA-4608870Reactome: R-HSA-4641257Reactome: R-HSA-4641258Reactome: R-HSA-5358346Reactome: R-HSA-5362768Reactome: R-HSA-5607761Reactome: R-HSA-5607764Reactome: R-HSA-5610780Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5632684Reactome: R-HSA-5658442Reactome: R-HSA-5668541Reactome: R-HSA-5676590Reactome: R-HSA-5678895Reactome: R-HSA-5687128Reactome: R-HSA-5689603Reactome: R-HSA-5689880Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-69017Reactome: R-HSA-69481Reactome: R-HSA-69601Reactome: R-HSA-75815Reactome: R-HSA-8852276Reactome: R-HSA-8854050Reactome: R-HSA-8939236Reactome: R-HSA-8939902Reactome: R-HSA-8941858Reactome: R-HSA-8948751Reactome: R-HSA-8951664Reactome: R-HSA-9010553Reactome: R-HSA-9020702Reactome: R-HSA-9604323Reactome: R-HSA-9755511Reactome: R-HSA-9762114Reactome: R-HSA-9824272Reactome: R-HSA-983168Reactome: R-HSA-9907900 |
| Cellular Localisation | CytoplasmNucleusTranslocated From The Cytoplasm Into The Nucleus Following Interaction With Akirin2Which Bridges The Proteasome With The Nuclear Import Receptor Ipo9Colocalizes With Trim5 In The Cytoplasmic Bodies |
| Alternative Antibody Names | Anti-Proteasome Subunit Alpha Type-4 antibodyAnti-Macropain Subunit C9 antibodyAnti-Multicatalytic Endopeptidase Complex Subunit C9 antibodyAnti-Proteasome Component C9 antibodyAnti-Proteasome Subunit L antibodyAnti-Proteasome Subunit Alpha-3 antibodyAnti-Alpha-3 antibodyAnti-PSMA4 antibodyAnti-HC9 antibodyAnti-PSC9 antibody |
Information sourced from Uniprot.org
