| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
PSAP |
| Gene ID: |
5660 |
| Uniprot ID: |
SAP_HUMAN |
| Immunogen Region: |
275-524 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 275-524 of human PSAP (NP_002769.1). |
| Immunogen Sequence: |
KEMPMQTLVPAKVASKNVIP ALELVEPIKKHEVPAKSDVY CEVCEFLVKEVTKLIDNNKT EKEILDAFDKMCSKLPKSLS EECQEVVDTYGSSILSILLE EVSPELVCSMLHLCSGTRLP ALTVHVTQPKDGGFCEVCKK LVGYLDRNLEKNSTKQEILA ALEKGCSFLPDPYQKQCDQF VAEYEPVLIEILVEVMDPSF VCLKIGACPSAHKPLLGTEK CIWGPSYWCQNTETAAQCN |
| Post Translational Modifications | The lysosomal precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins. N-linked glycans show a high degree of microheterogeneity. The one residue extended Saposin-B-Val is only found in 5% of the chains. |
| Function | Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator. Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. |
| Protein Name | ProsaposinProactivator Polypeptide Cleaved Into - Saposin-AProtein A - Saposin-B-Val - Saposin-BCerebroside Sulfate ActivatorCsactDispersinSphingolipid Activator Protein 1Sap-1Sulfatide/Gm1 Activator - Saposin-CA1 ActivatorCo-Beta-GlucosidaseGlucosylceramidase ActivatorSphingolipid Activator Protein 2Sap-2 - Saposin-DComponent CProtein C |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | LysosomeProsaposin: SecretedSecreted As A Fully Glycosylated 70 Kda Protein Composed Of Complex Glycans |
| Alternative Antibody Names | Anti-Prosaposin antibodyAnti-Proactivator Polypeptide Cleaved Into - Saposin-A antibodyAnti-Protein A - Saposin-B-Val - Saposin-B antibodyAnti-Cerebroside Sulfate Activator antibodyAnti-Csact antibodyAnti-Dispersin antibodyAnti-Sphingolipid Activator Protein 1 antibodyAnti-Sap-1 antibodyAnti-Sulfatide/Gm1 Activator - Saposin-C antibodyAnti-A1 Activator antibodyAnti-Co-Beta-Glucosidase antibodyAnti-Glucosylceramidase Activator antibodyAnti-Sphingolipid Activator Protein 2 antibodyAnti-Sap-2 - Saposin-D antibodyAnti-Component C antibodyAnti-Protein C antibodyAnti-PSAP antibodyAnti-GLBA antibodyAnti-SAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
