| Tissue Specificity | Expressed in polymorphonuclear leukocytes (at protein level). Expressed in neutrophils (at protein level). Expressed in differentiating neutrophils. |
| Function | Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177. |
| Protein Name | MyeloblastinAgp7C-Anca AntigenLeukocyte Proteinase 3Pr-3Pr3Neutrophil Proteinase 4Np-4P29Wegener Autoantigen |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-449836Reactome: R-HSA-6798695Reactome: R-HSA-6803157 |
| Cellular Localisation | Cytoplasmic GranuleSecretedCell MembranePeripheral Membrane ProteinExtracellular SideMembrane RaftLocalizes Predominantly To Azurophil Granules (Primary Secretory Granules) In NeutrophilsSecreted Upon Neutrophil Stimulation By Tnf-AlphaLipopolysaccharide (Lps)Fmlp And Cxcl8/Il8 Or During Neutrophil TransmigrationFollowing Secretion Tethered To The Cell Membrane By Cd177 |
| Alternative Antibody Names | Anti-Myeloblastin antibodyAnti-Agp7 antibodyAnti-C-Anca Antigen antibodyAnti-Leukocyte Proteinase 3 antibodyAnti-Pr-3 antibodyAnti-Pr3 antibodyAnti-Neutrophil Proteinase 4 antibodyAnti-Np-4 antibodyAnti-P29 antibodyAnti-Wegener Autoantigen antibodyAnti-PRTN3 antibodyAnti-MBN antibody |
Information sourced from Uniprot.org
