Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-PRPF8 antibody (160-240 aa) (STJ191202)

SKU:
STJ191202
£48.00 - £252.00
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Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Pre-mRNA-processing-splicing factor 8 (160-240 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-300
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PRPF8
Gene ID: 10594
Uniprot ID: PRP8_HUMAN
Immunogen Region: 160-240 aa
Specificity: PRP8 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 160-240
Function Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Protein Name Pre-Mrna-Processing-Splicing Factor 8
220 Kda U5 Snrnp-Specific Protein
Prp8 Homolog
Splicing Factor Prp8
P220
Database Links Reactome: R-HSA-72163
Reactome: R-HSA-72165
Cellular Localisation Nucleus
Nucleus Speckle
Alternative Antibody Names Anti-Pre-Mrna-Processing-Splicing Factor 8 antibody
Anti-220 Kda U5 Snrnp-Specific Protein antibody
Anti-Prp8 Homolog antibody
Anti-Splicing Factor Prp8 antibody
Anti-P220 antibody
Anti-PRPF8 antibody
Anti-PRPC8 antibody

Information sourced from Uniprot.org

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