Anti-PRPF3 antibody (STJA0007332)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PRPF3
General Information
| Short Description | Rabbit polyclonal anti-U4/U6 small nuclear ribonucleoprotein Prp3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRPF3 |
| Gene ID | 9129 |
| Uniprot ID | PRPF3_HUMAN |
| Immunogen | Synthesized peptide derived from human PRPF3 |
| Specificity | This antibody detects endogenous levels of PRPF3 at Human, Mouse |
Additional Info
| Post Translational Modifications | Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination by PRPF19 and deubiquitination by USP4. 'Lys-63'-linked ubiquitination increases the affinity for PRPF8 and may regulate the assembly of the U4/U6-U5 tri-snRNP complex. |
| Function | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). |
| Protein Name | U4/U6 Small Nuclear Ribonucleoprotein Prp3Pre-Mrna-Splicing Factor 3Hprp3U4/U6 Snrnp 90 Kda Protein |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-U4/U6 Small Nuclear Ribonucleoprotein Prp3 antibodyAnti-Pre-Mrna-Splicing Factor 3 antibodyAnti-Hprp3 antibodyAnti-U4/U6 Snrnp 90 Kda Protein antibodyAnti-PRPF3 antibodyAnti-HPRP3 antibodyAnti-PRP3 antibody |
Information sourced from Uniprot.org