Anti-PRKG2 antibody (92-141 aa) (STJ92256)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human PKG2 at the amino acid range 92-141
General Information
| Short Description | Rabbit polyclonal anti-cGMP-dependent protein kinase 2 (92-141 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PRKG2 |
| Gene ID | 5593 |
| Uniprot ID | KGP2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human PKG2 at the amino acid range 92-141 |
| Immunogen Region | 92-141 aa |
| Specificity | cGKII Polyclonal Antibody detects endogenous levels of cGKII protein. |
Additional Info
| Post Translational Modifications | Myristoylation mediates membrane localization. |
| Function | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation. |
| Protein Name | Cgmp-Dependent Protein Kinase 2Cgk 2Cgk2Cgmp-Dependent Protein Kinase IiCgkii |
| Database Links | Reactome: R-HSA-1474151Reactome: R-HSA-4086398Reactome: R-HSA-418457Reactome: R-HSA-9648002 |
| Cellular Localisation | Apical Cell MembraneLipid-Anchor |
| Alternative Antibody Names | Anti-Cgmp-Dependent Protein Kinase 2 antibodyAnti-Cgk 2 antibodyAnti-Cgk2 antibodyAnti-Cgmp-Dependent Protein Kinase Ii antibodyAnti-Cgkii antibodyAnti-PRKG2 antibodyAnti-PRKGR2 antibody |
Information sourced from Uniprot.org