Anti-PREX2 antibody (720-900) {Biotin} (STJ502652)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 720-900 on PREX2 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-PREX2 (720-900) is suitable for use in ELISA and Western Blot research applications. |
| Applications | ELISA/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.65 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500-1:750DB: 1:20, 000-1:50, 000ELISA: 1:20, 000-1:50, 000 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PREX2 |
| Gene ID | 80243 |
| Uniprot ID | PREX2_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 720-900 on PREX2 protein. |
| Immunogen Region | 720-900 |
Additional Info
| Tissue Specificity | Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. |
| Function | Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. |
| Protein Name | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 2 ProteinP-Rex2Ptdins(3 -4 -5-Dependent Rac Exchanger 2Dep Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-8948751Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Alternative Antibody Names | Anti-Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 2 Protein antibodyAnti-P-Rex2 antibodyAnti-Ptdins(3 -4 -5-Dependent Rac Exchanger 2 antibodyAnti-Dep Domain-Containing Protein 2 antibodyAnti-PREX2 antibodyAnti-DEPDC2 antibody |
Information sourced from Uniprot.org