| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PREPL |
| Gene ID: | 9581 |
| Uniprot ID: | PPCEL_HUMAN |
| Immunogen Region: | 578-727 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 578-727 of human PREPL (NP_006027.2). |
| Immunogen Sequence: | AVTLEAPFLDVLNTMMDTTL PLTLEELEEWGNPSSDEKHK NYIKRYCPYQNIKPQHYPSI HITAYENDERVPLKGIVSYT EKLKEAIAEHAKDTGEGYQT PNIILDIQPGGNHVIEDSHK KITAQIKFLYEELGLDSTSV FEDLKKYLKF |
| Tissue Specificity | Expressed in pyramidal neurons of the temporal cortex and neocortex (at protein level). Widely expressed. Expressed at higher level in brain, skeletal muscle, heart and kidney. Expressed at the endplates in the neuromuscular junction. |
| Function | Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis. |
| Protein Name | Prolyl Endopeptidase-LikeProlylendopeptidase-Like |
| Cellular Localisation | CytoplasmCytosolGolgi ApparatusTrans-Golgi NetworkCytoskeletonNucleusCo-Localizes With Ap-1 In The Trans-Golgi NetworkCo-Localizes With Map2 And Actb On The CytoskeletonCo-Localizes With Stx6 And Gosr2 At The Golgi Apparatus |
| Alternative Antibody Names | Anti-Prolyl Endopeptidase-Like antibodyAnti-Prolylendopeptidase-Like antibodyAnti-PREPL antibodyAnti-KIAA0436 antibody |
Information sourced from Uniprot.org