| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Prolactin regulatory element-binding protein is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PREB |
| Gene ID: |
10113 |
| Uniprot ID: |
SEC12_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PREB at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PREB |
| Function | Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases. In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi. Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. |
| Protein Name | Guanine Nucleotide-Exchange Factor Sec12Prolactin Regulatory Element-Binding Protein |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-381038Reactome: R-HSA-5694530 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleusConcentrates At Endoplasmic Reticulum Exit Sites (Eres)Also Known As Transitional Endoplasmic Reticulum (Ter) |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Exchange Factor Sec12 antibodyAnti-Prolactin Regulatory Element-Binding Protein antibodyAnti-PREB antibodyAnti-SEC12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
