| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Prealbumin/Transthyretin (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Preliminary experiments gave an approx 20-22kDa band in Human Heart, Kidney, Liver, Lung, Placenta and Testis lysates after 1µg/ml antibody staining. Please note that currently we canno |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TTR |
| Gene ID: | 7276 |
| Uniprot ID: | TTHY_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_000362.1 |
| Immunogen Sequence: | YKVEIDTKSYWK |
| Post Translational Modifications | Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYLD1 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation. |
| Function | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. |
| Protein Name | TransthyretinAttrPrealbuminTbpa |
| Database Links | Reactome: R-HSA-2453864Reactome: R-HSA-2453902Reactome: R-HSA-3000171Reactome: R-HSA-6798695Reactome: R-HSA-975634Reactome: R-HSA-977225 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Antibody Names | Anti-Transthyretin antibodyAnti-Attr antibodyAnti-Prealbumin antibodyAnti-Tbpa antibodyAnti-TTR antibodyAnti-PALB antibody |
Information sourced from Uniprot.org
