| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-prealbumin/transthyretin (62-74) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000. WB: Approx 16kDa band observed in Human Albumin-depleted Serum (calculated MW of 15.9kDa according to NP_000362.1). Recommended concentration: 0.01-0.03µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TTR |
| Gene ID: | 7276 |
| Uniprot ID: | TTHY_HUMAN |
| Immunogen Region: | 62-74 |
| Accession Number: | NP_000362.1 |
| Immunogen Sequence: | EPFASGKTSESGE |
| Post Translational Modifications | Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYLD1 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation. |
| Function | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. |
| Protein Name | Transthyretin Attr Prealbumin Tbpa |
| Database Links | Reactome: R-HSA-2453864 Reactome: R-HSA-2453902 Reactome: R-HSA-3000171 Reactome: R-HSA-6798695 Reactome: R-HSA-975634 Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted Cytoplasm |
| Alternative Antibody Names | Anti-Transthyretin antibody Anti-Attr antibody Anti-Prealbumin antibody Anti-Tbpa antibody Anti-TTR antibody Anti-PALB antibody |
Information sourced from Uniprot.org