Host: | Rabbit |
Applications: | WB/IHC/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-Peroxiredoxin 3 (157-256) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Monoclonal |
Clone ID: | S9MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PRDX3 |
Gene ID: | 10935 |
Uniprot ID: | PRDX3_HUMAN |
Immunogen Region: | 157-256 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 157-256 of human Peroxiredoxin 3 (PRDX3) (PRDX3) (P30048). |
Immunogen Sequence: | NIALLSDLTKQISRDYGVLL EGSGLALRGLFIIDPNGVIK HLSVNDLPVGRSVEETLRLV KAFQYVETHGEVCPANWTPD SPTIKPSPAASKEYFQKVNQ |
Post Translational Modifications | Phosphorylated by LRRK2.phosphorylation reduces perodixase activity. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. S-palmitoylated. |
Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength. |
Protein Name | Thioredoxin-Dependent Peroxide Reductase - Mitochondrial Antioxidant Protein 1 Aop-1 Hbc189 Peroxiredoxin Iii Prx-Iii Peroxiredoxin-3 Protein Mer5 Homolog Thioredoxin-Dependent Peroxiredoxin 3 |
Database Links | Reactome: R-HSA-3299685 |
Cellular Localisation | Mitochondrion Cytoplasm Early Endosome Localizes To Early Endosomes In A Rps6kc1-Dependent Manner |
Alternative Antibody Names | Anti-Thioredoxin-Dependent Peroxide Reductase - Mitochondrial antibody Anti-Antioxidant Protein 1 antibody Anti-Aop-1 antibody Anti-Hbc189 antibody Anti-Peroxiredoxin Iii antibody Anti-Prx-Iii antibody Anti-Peroxiredoxin-3 antibody Anti-Protein Mer5 Homolog antibody Anti-Thioredoxin-Dependent Peroxiredoxin 3 antibody Anti-PRDX3 antibody Anti-AOP1 antibody |
Information sourced from Uniprot.org