| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Peroxiredoxin-2 (1-142) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRDX2 |
| Gene ID: |
7001 |
| Uniprot ID: |
PRDX2_HUMAN |
| Immunogen Region: |
1-142 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human PRDX1/PRDX2 (NP_859428.1). |
| Immunogen Sequence: |
MASGNARIGKPAPDFKATAV VDGAFKEVKLSDYKGKYVVL FFYPLDFTFVCPTEIIAFSN RAEDFRKLGCEVLGVSVDSQ FTHLAWYEQGPKREVAAKLT PSGPSSVASWPLLNLWNLRF PIVKIMETLPPKSLRMMTVI SI |
| Post Translational Modifications | The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). |
| Protein Name | Peroxiredoxin-2Natural Killer Cell-Enhancing Factor BNkef-BPrpThiol-Specific Antioxidant ProteinTsaThioredoxin Peroxidase 1Thioredoxin-Dependent Peroxide Reductase 1Thioredoxin-Dependent Peroxiredoxin 2 |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-5628897Reactome: R-HSA-8862803 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Peroxiredoxin-2 antibodyAnti-Natural Killer Cell-Enhancing Factor B antibodyAnti-Nkef-B antibodyAnti-Prp antibodyAnti-Thiol-Specific Antioxidant Protein antibodyAnti-Tsa antibodyAnti-Thioredoxin Peroxidase 1 antibodyAnti-Thioredoxin-Dependent Peroxide Reductase 1 antibodyAnti-Thioredoxin-Dependent Peroxiredoxin 2 antibodyAnti-PRDX2 antibodyAnti-NKEFB antibodyAnti-TDPX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
