| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
PRDM8 |
| Gene ID: |
56978 |
| Uniprot ID: |
PRDM8_HUMAN |
| Immunogen Region: |
1-280 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PRDM8 (NP_064611.3). |
| Immunogen Sequence: |
MEDTGIQRGIWDGDAKAVQQ CLTDIFTSVYTTCDIPENAI FGPCVLSHTSLYDSIAFIAL KSTDKRTVPYIFRVDTSAAN GSSEGLMWLRLVQSARDKEE QNLEAYIKNGQLFYRSLRRI AKDEELLVWYGKELTELLLL CPSRSHNKMNGSSPYTCLEC SQRFQFEFPYVAHLRFRCPK RLHSADISPQDEQGGGVGTK DHGGGGGGGKDQQQQQQEAP LGPGPKFCKAGPLHHYPSP |
| Tissue Specificity | Expressed in brain, heart, skeletal muscle, testes, prostate. |
| Function | Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR. Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival. |
| Protein Name | Pr Domain Zinc Finger Protein 8Pr Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-9762293 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pr Domain Zinc Finger Protein 8 antibodyAnti-Pr Domain-Containing Protein 8 antibodyAnti-PRDM8 antibodyAnti-PFM5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
