Anti-PRDM1/BLIMP1 antibody (C-Term) (STJ70276)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PRDM1/BLIMP1 (C-Term) is suitable for use in ELISA, Immunofluorescence and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IF/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.IHC: Paraffin embedded Human Tonsil. Recommended concentration: 5-6µg/ml.IF: Strong expression of the protein seen in the nucleus and plasma membrane of U251 cells. Recommended concent |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PRDM1 |
| Gene ID | 639 |
| Uniprot ID | PRDM1_HUMAN |
| Accession Number | NP_001189.2; NP_878911.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | KVKQETVEPMDP |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_001189.2 and NP_878911.1). |
Additional Info
| Function | Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1. |
| Protein Name | Pr Domain Zinc Finger Protein 1Blimp-1Beta-Interferon Gene Positive Regulatory Domain I-Binding FactorPr Domain-Containing Protein 1Positive Regulatory Domain I-Binding Factor 1Prdi-Bf1Prdi-Binding Factor 1 |
| Database Links | Reactome: R-HSA-6804754Reactome: R-HSA-9701898Reactome: R-HSA-9827857 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pr Domain Zinc Finger Protein 1 antibodyAnti-Blimp-1 antibodyAnti-Beta-Interferon Gene Positive Regulatory Domain I-Binding Factor antibodyAnti-Pr Domain-Containing Protein 1 antibodyAnti-Positive Regulatory Domain I-Binding Factor 1 antibodyAnti-Prdi-Bf1 antibodyAnti-Prdi-Binding Factor 1 antibodyAnti-PRDM1 antibodyAnti-BLIMP1 antibody |
Information sourced from Uniprot.org