| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPP6C (1-305) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP6C |
| Gene ID: |
5537 |
| Uniprot ID: |
PPP6_HUMAN |
| Immunogen Region: |
1-305 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human PPP6C (NP_002712.1). |
| Immunogen Sequence: |
MAPLDLDKYVEIARLCKYLP ENDLKRLCDYVCDLLLEESN VQPVSTPVTVCGDIHGQFYD LCELFRTGGQVPDTNYIFMG DFVDRGYYSLETFTYLLALK AKWPDRITLLRGNHESRQIT QVYGFYDECQTKYGNANAWR YCTKVFDMLTVAALIDEQIL CVHGGLSPDIKTLDQIRTIE RNQEIPHKGAFCDLVWSDPE DVDTWAISPRGAGWLFGAKV TNEFVHINNLKLICRAHQL |
| Tissue Specificity | Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. |
| Function | Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation. Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1. CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it. |
| Protein Name | Serine/Threonine-Protein Phosphatase 6 Catalytic SubunitPp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-204005 |
| Cellular Localisation | MitochondrionCytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit antibodyAnti-Pp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed antibodyAnti-PPP6C antibodyAnti-PPP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
