Anti-PPP3R1 antibody (11-170) (STJ25094)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PPP3R1 (11-170) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP3R1 |
| Gene ID | 5534 |
| Uniprot ID | CANB1_HUMAN |
| Immunogen Region | 11-170 |
| Immunogen Sequence | MCSHFDADEIKRLGKRFKKL DLDNSGSLSVEEFMSLPELQ QNPLVQRVIDIFDTDGNGEV DFKEFIEGVSQFSVKGDKEQ KLRFAFRIYDMDKDGYISNG ELFQVLKMMVGNNLKDTQLQ QIVDKTIINADKDGDGRISF EEFCAVVGGLDIHKKMVVDV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 11-170 of human PPP3R1 (NP_000936.1). |
Additional Info
| Function | Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. |
| Protein Name | Calcineurin Subunit B Type 1Protein Phosphatase 2b Regulatory Subunit 1Protein Phosphatase 3 Regulatory Subunit B Alpha Isoform 1 |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-180024Reactome: R-HSA-2025928Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-5607763 |
| Cellular Localisation | CytoplasmCytosolCell MembraneSarcolemmaLipid-AnchorTranslocates From The Cytosol To The Sarcolemma In A Cib1-Dependent Manner During Cardiomyocyte Hypertrophy |
| Alternative Antibody Names | Anti-Calcineurin Subunit B Type 1 antibodyAnti-Protein Phosphatase 2b Regulatory Subunit 1 antibodyAnti-Protein Phosphatase 3 Regulatory Subunit B Alpha Isoform 1 antibodyAnti-PPP3R1 antibodyAnti-CNA2 antibodyAnti-CNB antibody |
Information sourced from Uniprot.org