Anti-PPIL2 antibody (STJA0008015)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PPIL2
General Information
| Short Description | Rabbit polyclonal anti-RING-type E3 ubiquitin-protein ligase PPIL2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPIL2 |
| Gene ID | 23759 |
| Uniprot ID | PPIL2_HUMAN |
| Immunogen | Synthesized peptide derived from human PPIL2 |
| Specificity | This antibody detects endogenous levels of PPIL2 at Human, Mouse |
Additional Info
| Function | Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). |
| Protein Name | Ring-Type E3 Ubiquitin-Protein Ligase Ppil2Cyc4Cyclophilin-60Cyclophilin-Like Protein Cyp-60Cyp60Hcyp-60Probable Inactive Peptidyl-Prolyl Cis-Trans Isomerase-Like 2PpiaseRotamase Ppil2 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusMay Also Localize To The Cytoplasm And The Cell Membrane |
| Alternative Antibody Names | Anti-Ring-Type E3 Ubiquitin-Protein Ligase Ppil2 antibodyAnti-Cyc4 antibodyAnti-Cyclophilin-60 antibodyAnti-Cyclophilin-Like Protein Cyp-60 antibodyAnti-Cyp60 antibodyAnti-Hcyp-60 antibodyAnti-Probable Inactive Peptidyl-Prolyl Cis-Trans Isomerase-Like 2 antibodyAnti-Ppiase antibodyAnti-Rotamase Ppil2 antibodyAnti-PPIL2 antibody |
Information sourced from Uniprot.org