| Function | Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). |
| Protein Name | Ring-Type E3 Ubiquitin-Protein Ligase Ppil2Cyc4Cyclophilin-60Cyclophilin-Like Protein Cyp-60Cyp60Hcyp-60Probable Inactive Peptidyl-Prolyl Cis-Trans Isomerase-Like 2PpiaseRotamase Ppil2 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusMay Also Localize To The Cytoplasm And The Cell Membrane |
| Alternative Antibody Names | Anti-Ring-Type E3 Ubiquitin-Protein Ligase Ppil2 antibodyAnti-Cyc4 antibodyAnti-Cyclophilin-60 antibodyAnti-Cyclophilin-Like Protein Cyp-60 antibodyAnti-Cyp60 antibodyAnti-Hcyp-60 antibodyAnti-Probable Inactive Peptidyl-Prolyl Cis-Trans Isomerase-Like 2 antibodyAnti-Ppiase antibodyAnti-Rotamase Ppil2 antibodyAnti-PPIL2 antibody |
Information sourced from Uniprot.org
