| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPID (161-370) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPID |
| Gene ID: |
5481 |
| Uniprot ID: |
PPID_HUMAN |
| Immunogen Region: |
161-370 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 161-370 of human Cyclophilin 40 (NP_005029.1). |
| Immunogen Sequence: |
ILENVEVKGEKPAKLCVIAE CGELKEGDDGGIFPKDGSGD SHPDFPEDADIDLKDVDKIL LITEDLKNIGNTFFKSQNWE MAIKKYAEVLRYVDSSKAVI ETADRAKLQPIALSCVLNIG ACKLKMSNWQGAIDSCLEAL ELDPSNTKALYRRAQGWQGL KEYDQALADLKKAQGIAPED KAIQAELLKVKQKIKAQKDK EKAVYAKMFA |
| Tissue Specificity | Widely expressed. |
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer.the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase DPpiase D40 Kda Peptidyl-Prolyl Cis-Trans IsomeraseCyclophilin-40Cyp-40Cyclophilin-Related ProteinRotamase D |
| Database Links | Reactome: R-HSA-8939211 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasm |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase D antibodyAnti-Ppiase D antibodyAnti-40 Kda Peptidyl-Prolyl Cis-Trans Isomerase antibodyAnti-Cyclophilin-40 antibodyAnti-Cyp-40 antibodyAnti-Cyclophilin-Related Protein antibodyAnti-Rotamase D antibodyAnti-PPID antibodyAnti-CYP40 antibodyAnti-CYPD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
