| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Platelet basic protein (71-120 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200 ELISA 1:10000-20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPBP |
| Gene ID: | 5473 |
| Uniprot ID: | CXCL7_HUMAN |
| Immunogen Region: | 71-120 aa |
| Specificity: | The antibody detects endogenous PBP |
| Immunogen: | Synthetic peptide from the human protein at the amino acid range 71-120 |
| Function | LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. |
| Protein Name | Platelet Basic Protein Pbp C-X-C Motif Chemokine 7 Leukocyte-Derived Growth Factor Ldgf Macrophage-Derived Growth Factor Mdgf Small-Inducible Cytokine B7 Cleaved Into - Connective Tissue-Activating Peptide Iii Ctap-Iii La-Pf4 Low-Affinity Platelet Factor Iv - Tc-2 - Connective Tissue-Activating Peptide Iii(1-81 Ctap-Iii(1-81 - Beta-Thromboglobulin Beta-Tg - Neutrophil-Activating Peptide 2(74 Nap-2(74 - Neutrophil-Activating Peptide 2(73 Nap-2(73 - Neutrophil-Activating Peptide 2 Nap-2 - Tc-1 - Neutrophil-Activating Peptide 2(1-66 Nap-2(1-66 - Neutrophil-Activating Peptide 2(1-63 Nap-2(1-63 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Platelet Basic Protein antibody Anti-Pbp antibody Anti-C-X-C Motif Chemokine 7 antibody Anti-Leukocyte-Derived Growth Factor antibody Anti-Ldgf antibody Anti-Macrophage-Derived Growth Factor antibody Anti-Mdgf antibody Anti-Small-Inducible Cytokine B7 Cleaved Into - Connective Tissue-Activating Peptide Iii antibody Anti-Ctap-Iii antibody Anti-La-Pf4 antibody Anti-Low-Affinity Platelet Factor Iv - Tc-2 - Connective Tissue-Activating Peptide Iii(1-81 antibody Anti-Ctap-Iii(1-81 - Beta-Thromboglobulin antibody Anti-Beta-Tg - Neutrophil-Activating Peptide 2(74 antibody Anti-Nap-2(74 - Neutrophil-Activating Peptide 2(73 antibody Anti-Nap-2(73 - Neutrophil-Activating Peptide 2 antibody Anti-Nap-2 - Tc-1 - Neutrophil-Activating Peptide 2(1-66 antibody Anti-Nap-2(1-66 - Neutrophil-Activating Peptide 2(1-63 antibody Anti-Nap-2(1-63 antibody Anti-PPBP antibody Anti-CTAP3 antibody Anti-CXCL7 antibody Anti-SCYB7 antibody Anti-TGB1 antibody Anti-THBGB1 antibody |
Information sourced from Uniprot.org