Anti-PPARD antibody [2F9] (STJ97707)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant Protein of PPAR Delta of PPAR Delta
General Information
| Short Description | Mouse monoclonal anti-Peroxisome proliferator-activated receptor delta for use in IF and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC |
| Host | Mouse |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2F9 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IF 1:50-200IHC 1:100-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPARD |
| Gene ID | 5467 |
| Uniprot ID | PPARD_HUMAN |
| Immunogen | Recombinant Protein of PPAR Delta of PPAR Delta |
| Specificity | PPAR Delta protein detects endogenous levels of PPAR Delta |
Additional Info
| Post Translational Modifications | 'Lys-48'-linked polyubiquitinated.leading to proteasomal degradation. Deubiquitinated and stabilized by OTUD3. |
| Function | Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. |
| Protein Name | Peroxisome Proliferator-Activated Receptor DeltaPpar-DeltaNuciNuclear Hormone Receptor 1Nuc1Nuclear Receptor Subfamily 1 Group C Member 2Peroxisome Proliferator-Activated Receptor BetaPpar-Beta |
| Database Links | Reactome: R-HSA-200425Reactome: R-HSA-383280Reactome: R-HSA-5362517 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Peroxisome Proliferator-Activated Receptor Delta antibodyAnti-Ppar-Delta antibodyAnti-Nuci antibodyAnti-Nuclear Hormone Receptor 1 antibodyAnti-Nuc1 antibodyAnti-Nuclear Receptor Subfamily 1 Group C Member 2 antibodyAnti-Peroxisome Proliferator-Activated Receptor Beta antibodyAnti-Ppar-Beta antibodyAnti-PPARD antibodyAnti-NR1C2 antibodyAnti-PPARB antibody |
Information sourced from Uniprot.org