| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPAR alpha (1-92) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPARA |
| Gene ID: |
5465 |
| Uniprot ID: |
PPARA_HUMAN |
| Immunogen Region: |
1-92 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human PPAR Alpha (NP_005027.2). |
| Immunogen Sequence: |
MVDTESPLCPLSPLEAGDLE SPLSEEFLQEMGNIQEISQS IGEDSSGSFGFTEYQYLGSC PGSDGSVITDTLSPASSPSS VTYPVVPGSVDE |
| Tissue Specificity | Skeletal muscle, liver, heart and kidney. Expressed in monocytes. |
| Function | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. |
| Protein Name | Peroxisome Proliferator-Activated Receptor AlphaPpar-AlphaNuclear Receptor Subfamily 1 Group C Member 1 |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-4090294Reactome: R-HSA-9707564Reactome: R-HSA-9707616 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Peroxisome Proliferator-Activated Receptor Alpha antibodyAnti-Ppar-Alpha antibodyAnti-Nuclear Receptor Subfamily 1 Group C Member 1 antibodyAnti-PPARA antibodyAnti-NR1C1 antibodyAnti-PPAR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
