| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Pou Domain-Class 2-Transcription Factor 2 (400-479) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POU2F2 |
| Gene ID: |
5452 |
| Uniprot ID: |
PO2F2_HUMAN |
| Immunogen Region: |
400-479 |
| Immunogen: |
Recombinant fusion protein containing a sequence within amino acids 400-479 of human POU2F2 (NP_001193954.1). |
| Immunogen Sequence: |
VTTLSSAVGTLHPSRTAGGG GGGGGAAPPLNSIPSVTPPP PATTNSTNPSPQGSHSAIGL SGLNPSTGPGLWWNPAPYQP |
| Tissue Specificity | Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. |
| Function | Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1. Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5: Activates the U2 small nuclear RNA (snRNA) promoter. |
| Protein Name | Pou Domain - Class 2 - Transcription Factor 2Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein Nf-A2Octamer-Binding Protein 2Oct-2Octamer-Binding Transcription Factor 2Otf-2 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Pou Domain - Class 2 - Transcription Factor 2 antibodyAnti-Lymphoid-Restricted Immunoglobulin Octamer-Binding Protein Nf-A2 antibodyAnti-Octamer-Binding Protein 2 antibodyAnti-Oct-2 antibodyAnti-Octamer-Binding Transcription Factor 2 antibodyAnti-Otf-2 antibodyAnti-POU2F2 antibodyAnti-OCT2 antibodyAnti-OTF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
