Anti-POU2F1/OCT1 antibody (Internal) (STJ72230)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-POU2F1/OCT1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 100kDa band observed in nuclear lysates of cell line HeLa (calculated MW of 76.5kDa according to NP_002688.2). This molecular weight is routinely observed by other sources. Recom |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | POU2F1 |
| Gene ID | 5451 |
| Uniprot ID | PO2F1_HUMAN |
| Accession Number | NP_002688.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | NVQSKSNEESGDSQQ |
Additional Info
| Post Translational Modifications | Phosphorylated by PRKDC. |
| Function | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. |
| Protein Name | Pou Domain - Class 2 - Transcription Factor 1Nf-A1Octamer-Binding Protein 1Oct-1Octamer-Binding Transcription Factor 1Otf-1 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-6807505Reactome: R-HSA-749476Reactome: R-HSA-76071Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pou Domain - Class 2 - Transcription Factor 1 antibodyAnti-Nf-A1 antibodyAnti-Octamer-Binding Protein 1 antibodyAnti-Oct-1 antibodyAnti-Octamer-Binding Transcription Factor 1 antibodyAnti-Otf-1 antibodyAnti-POU2F1 antibodyAnti-OCT1 antibodyAnti-OTF1 antibody |
Information sourced from Uniprot.org