| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PON2 |
| Gene ID: | 5445 |
| Uniprot ID: | PON2_HUMAN |
| Immunogen Region: | 1-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PON2 (NP_000296.2). |
| Immunogen Sequence: | MGRLVAVGLLGIALALLGER LLALRNRLKASREVESVDLP HCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPD KPGGILMMDLKEEKPRAREL RISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTV EIFKFEEAENSLLHLKTVKH ELLPSVNDITAVGPAHFYAT NDHYFSDPFLKYLETYLNLH WANVVYYSPN |
| Tissue Specificity | Widely expressed with highest expression in liver, lung, placenta, testis and heart. |
| Post Translational Modifications | The signal sequence is not cleaved. |
| Function | Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. |
| Protein Name | Serum Paraoxonase/Arylesterase 2Pon 2Aromatic Esterase 2A-Esterase 2Serum Aryldialkylphosphatase 2 |
| Database Links | Reactome: R-HSA-2142688 |
| Cellular Localisation | MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Serum Paraoxonase/Arylesterase 2 antibodyAnti-Pon 2 antibodyAnti-Aromatic Esterase 2 antibodyAnti-A-Esterase 2 antibodyAnti-Serum Aryldialkylphosphatase 2 antibodyAnti-PON2 antibody |
Information sourced from Uniprot.org