• Western blot analysis of lysates from wild type (WT) and PON2 knockout (KO) HeLa cells, using [KO Validated] PON2 Rabbit polyclonal antibody (STJ11100728) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-PON2 antibody (1-210) (STJ11100728)

SKU:
STJ11100728

£129.50 - £639.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PON2 (1-210) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PON2
Gene ID: 5445
Uniprot ID: PON2_HUMAN
Immunogen Region: 1-210
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PON2 (NP_000296.2).
Immunogen Sequence: MGRLVAVGLLGIALALLGER LLALRNRLKASREVESVDLP HCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPD KPGGILMMDLKEEKPRAREL RISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTV EIFKFEEAENSLLHLKTVKH ELLPSVNDITAVGPAHFYAT NDHYFSDPFLKYLETYLNLH WANVVYYSPN
Tissue Specificity Widely expressed with highest expression in liver, lung, placenta, testis and heart.
Post Translational Modifications The signal sequence is not cleaved.
Function Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
Protein Name Serum Paraoxonase/Arylesterase 2
Pon 2
Aromatic Esterase 2
A-Esterase 2
Serum Aryldialkylphosphatase 2
Database Links Reactome: R-HSA-2142688
Cellular Localisation Membrane
Peripheral Membrane Protein
Alternative Antibody Names Anti-Serum Paraoxonase/Arylesterase 2 antibody
Anti-Pon 2 antibody
Anti-Aromatic Esterase 2 antibody
Anti-A-Esterase 2 antibody
Anti-Serum Aryldialkylphosphatase 2 antibody
Anti-PON2 antibody

Information sourced from Uniprot.org

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