| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-PON1/paraoxonase 1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx. 37kDa band observed in Human Liver lysates (calculated MW of 39.7kDa according to NP_000437.3). Recommended concentration: 1-3µg/ml. Primary incubation was 1 hour. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PON1 |
| Gene ID: | 5444 |
| Uniprot ID: | PON1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_000437.3 |
| Immunogen Sequence: | EEPKVTQVYAEN |
| Post Translational Modifications | Glycosylated. The signal sequence is not cleaved. Present in two forms, form B contains a disulfide bond, form A does not. |
| Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. |
| Protein Name | Serum Paraoxonase/Arylesterase 1Pon 1 Aromatic Esterase 1A-Esterase 1K-45Serum Aryldialkylphosphatase 1 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-9754706 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Serum Paraoxonase/Arylesterase 1 antibodyAnti-Pon 1 antibodyAnti-Aromatic Esterase 1 antibodyAnti-A-Esterase 1 antibodyAnti-K-45 antibodyAnti-Serum Aryldialkylphosphatase 1 antibodyAnti-PON1 antibodyAnti-PON antibody |
Information sourced from Uniprot.org